Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.47 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.43 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10700517 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2DRD1DRD4DRD5KDM4E | |
| Hydrochloric Acid SCHEMBL10703667 | 0.89 | DRD1 (0.55) | DRD1DRD4DRD5DRD2DRD3 | |
| Fumaric Acid SCHEMBL11169294 | 0.81 | MEN1 (0.43) | SMN1; SMN2DRD1DRD4DRD5KDM4E | |
| Fumaric Acid SCHEMBL11169280 | 0.81 | MEN1 (0.43) | SMN1; SMN2DRD1DRD4DRD5KDM4E | |
| SCHEMBL10700513 | 0.80 | CYP3A4 (0.47) | SMN1; SMN2DRD1DRD5KDM4ENPY1R | |
| SCHEMBL10702082 | 0.79 | ESR1 (0.50) | KDM4EKMT2AALOX15HSD17B10NPC1 | |
| Fumaric Acid SCHEMBL10702746 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2DRD1DRD4DRD5KDM4E | |
| Fumaric Acid SCHEMBL10702753 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2DRD1DRD4DRD5KDM4E | |
| SCHEMBL10704701 | 0.74 | HTR2C (0.50) | DRD1DRD5KMT2AALOX15HSD17B10 | |
| SCHEMBL10701215 | 0.74 | DRD1 (0.53) | SMN1; SMN2DRD1DRD4DRD5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285287-A2 | 3-Benzazepine compounds for use in treating gastrointestinal motility disorders | SMITHKLINE BEECHAM CORPORATION (US) | 1988-10-05 | — | — | EP | disclosed |