Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700306 | 0.89 | MAPT (0.51) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2485964 | 0.89 | LMNA (0.47) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10709260 | 0.88 | MAPT (0.49) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10700803 | 0.88 | MAPT (0.48) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10696183 | 0.86 | MAPT (0.51) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2488921 | 0.85 | LMNA (0.51) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10699942 | 0.85 | MAPT (0.51) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10699123 | 0.85 | MAPT (0.52) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10695938 | 0.84 | MAPT (0.52) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2490057 | 0.81 | MAPT (0.58) | LMNAMAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |