Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | MMP2 | P08253 | 4/20 | 0.53 |
| ▸ | MMP9 | P14780 | 4/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.53 |
| ▸ | NPBWR1 | P48145 | 12/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698143 | 0.86 | AURKA (0.59) | AURKAAURKBRAB9ANPC1MAPT | |
| SCHEMBL10698507 | 0.86 | AURKB (0.59) | AURKAAURKBNPBWR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10696315 | 0.86 | AURKA (0.56) | AURKAAURKBRAB9ANPC1MAPT | |
| SCHEMBL10698462 | 0.86 | AURKA (0.58) | AURKAAURKBNPBWR1 | |
| SCHEMBL10696602 | 0.85 | AURKA (0.60) | AURKAAURKBRAB9ANPC1ALDH1A1 | |
| SCHEMBL10697452 | 0.84 | AURKB (0.57) | AURKAAURKBRAB9ANPC1MAPT | |
| SCHEMBL10699037 | 0.84 | AURKA (0.57) | AURKAAURKBRAB9ANPC1MAPT | |
| SCHEMBL10701197 | 0.84 | AURKA (0.57) | AURKAAURKBRAB9ANPC1MAPT | |
| SCHEMBL10699579 | 0.84 | AURKA (0.57) | AURKAAURKBMAPTMEN1KMT2A | |
| SCHEMBL5189691 | 0.83 | AURKA (0.54) | AURKAAURKBRAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |