Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391649 | 0.91 | GPR119 (0.46) | TBK1GPR119KDM4EPKMLIMK2 | |
| SCHEMBL390308 | 0.90 | TBK1 (0.46) | TBK1GPR119LIMK2TGFBR1 | |
| SCHEMBL387995 | 0.88 | GPR119 (0.47) | TBK1GPR119KDM4EPKMLIMK2 | |
| SCHEMBL391077 | 0.85 | TBK1 (0.47) | TBK1GPR119KDM4EPKMLIMK2 | |
| SCHEMBL391196 | 0.85 | TBK1 (0.45) | TBK1GPR119KDM4EPKMLIMK2 | |
| SCHEMBL391565 | 0.85 | TBK1 (0.45) | TBK1GPR119KDM4EPKMLIMK2 | |
| SCHEMBL391067 | 0.84 | GPR119 (0.47) | TBK1GPR119PIK3CAPRKDCSMN1; SMN2 | |
| SCHEMBL389112 | 0.84 | TBK1 (0.48) | TBK1GPR119PIK3CAPRKDCSMN1; SMN2 | |
| SCHEMBL389867 | 0.84 | TBK1 (0.46) | TBK1GPR119PIK3CAPRKDCCYP3A4 | |
| SCHEMBL386784 | 0.83 | GPR119 (0.46) | TBK1GPR119PIK3CAPRKDCCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |