Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10707421 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL10707242 | 0.93 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL10703598 | 0.91 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL10707531 | 0.83 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL10704091 | 0.83 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL10869451 | 0.82 | CASP1 (0.46) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL10704532 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6397973 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL10709061 | 0.79 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL10661157 | 0.78 | TSHR (0.44) | PDE4APDE4BPDE4CPDE4DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134922-B1 | 2-PIPERAZINO-PTERIDINES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1988-12-14 | — | — | EP | disclosed |
| US-4560685-A | 2-Piperazino-pteridines useful as antithrombotics and antimetastatics | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-12-24 | — | — | US | disclosed |
| EP-0134922-A1 | 2-Piperazino-pteridines, processes for their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-03-27 | — | — | EP | disclosed |