SCHEMBL10707196

SCHEMBL10707196

Nc1ccc(C=Cc2ccccc2Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 3/20 0.61
CYP1A2 P05177 2/20 0.61
CYP1A1 P04798 1/20 0.61
CYP1B1 Q16678 1/20 0.61
RELA Q04206 1/20 0.61
CYP19A1 P11511 6/20 0.59
MAOA P21397 1/20 0.59
MAOB P27338 1/20 0.59
CHAT P28329 1/20 0.58
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 2/20 0.49
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
APP P05067 2/20 0.47
HDAC1 Q13547 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
MEN1 O00255 2/20 0.42
MAPT P10636 2/20 0.42
KMT2A Q03164 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10707190 1.00 NFE2L2 (0.61) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL11296111 0.85 CYP19A1 (0.73) NFE2L2CYP19A1MAOAMAOBNPC1
SCHEMBL699771 0.83 NFE2L2 (0.66) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL699770 0.83 NFE2L2 (0.66) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL5493438 0.83 CHAT (0.66) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL5493433 0.83 CHAT (0.66) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL23332267 0.80 NFE2L2 (0.66) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL9586694 0.80 ALDH1A1 (0.62) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL1058814 0.80 ALDH1A1 (0.62) NFE2L2CYP1A2CYP1A1CYP1B1RELA
SCHEMBL2776707 0.79 CYP19A1 (0.64) NFE2L2CYP19A1MAOAMAOBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0150676-B1 1:2 CHROMIUM COMPLEX DYES CIBA-GEIGY AG (CH) 1988-10-12 EP disclosed
US-4650859-A WOOL,POLYAMIDES, LEATHER CIBA-GEIGY CORPORATION (US) 1987-03-17 US disclosed
EP-0150676-A2 1:2 Chromium complex dyes CIBA-GEIGY AG (CH) 1985-08-07 EP disclosed