Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | CDC42 | P60953 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 3/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16266669 | 0.71 | CDK4 (0.42) | SYKRPS6KB1CDK8 | |
| SCHEMBL19728686 | 0.71 | ADORA1 (0.42) | ROCK2ROCK1PKN2LMNA | |
| SCHEMBL6642020 | 0.70 | MAPT (0.50) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL15380926 | 0.70 | CDK2 (0.54) | SYKRPS6KB1CDK8 | |
| SCHEMBL11916208 | 0.69 | ULK1 (0.46) | CDK8 | |
| SCHEMBL30219582 | 0.69 | ULK1 (0.46) | CDK8 | |
| SCHEMBL12463242 | 0.67 | LMNA (0.53) | MMP1MMP3TACR3HDAC3HDAC1 | |
| SCHEMBL15028526 | 0.67 | LMNA (0.53) | MMP1MMP3TACR3HDAC3HDAC1 | |
| SCHEMBL30347548 | 0.65 | IDH1 (0.41) | RPS6KB1CDK8 | |
| SCHEMBL312895 | 0.65 | ADORA1 (0.42) | ROCK2ROCK1PKN2SYKCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |