Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | USP5 | P45974 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875993 | 0.86 | USP5 (0.49) | ALDH1A1USP5KMT2ANR4A2PKM | |
| SCHEMBL727064 | 0.84 | TSHR (0.59) | USP5KMT2ANR4A2PKMTSHR | |
| SCHEMBL3148795 | 0.84 | NR4A2 (0.53) | ALDH1A1USP5KMT2ANR4A2PKM | |
| SCHEMBL11706074 | 0.81 | CA2 (0.51) | ALDH1A1USP5KMT2ANR4A2PKM | |
| SCHEMBL11632016 | 0.81 | KMT2A (0.50) | ALDH1A1POLBUSP5KMT2ANR4A2 | |
| SCHEMBL28293607 | 0.80 | GSK3B (0.53) | ALDH1A1POLBTSHRHIF1AHPGD | |
| SCHEMBL10598079 | 0.79 | KMT2A (0.58) | ALDH1A1USP5KMT2ANR4A2PKM | |
| SCHEMBL11743831 | 0.79 | USP5 (0.49) | ALDH1A1USP5KMT2ANR4A2PKM | |
| SCHEMBL10764064 | 0.79 | KMT2A (0.58) | ALDH1A1USP5KMT2ANR4A2PKM | |
| SCHEMBL11736603 | 0.79 | KMT2A (0.49) | ALDH1A1USP5KMT2ANR4A2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172141-B1 | SUBSTITUTED PYRIDAZINONES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATION CONTAINING THESE COMPOUNDS AND THEIR USE | CIBA-GEIGY AG (CH) | 1988-12-07 | — | — | EP | disclosed |
| US-4624951-A | Substituted pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY CORPORATION (US) | 1986-11-25 | — | — | US | disclosed |
| EP-0172141-A1 | Substituted pyridazinones, method for their preparation, pharmaceutical preparation containing these compounds and their use | CIBA-GEIGY AG (CH) | 1986-02-19 | — | — | EP | disclosed |
| EP-0059688-B1 | PYRIDAZINONES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THEIR USE | CIBA-GEIGY AG (CH) | 1985-05-15 | — | — | EP | disclosed |
| EP-0059688-A1 | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use | CIBA-GEIGY AG (CH) | 1982-09-08 | — | — | EP | disclosed |