Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | USP5 | P45974 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148795 | 0.85 | NR4A2 (0.53) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL9365461 | 0.83 | GAA (0.57) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL30309808 | 0.83 | GAA (0.57) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL14757822 | 0.82 | HSD17B3 (0.56) | KMT2ATSHRRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10708232 | 0.81 | ALDH1A1 (0.50) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL10764064 | 0.81 | KMT2A (0.58) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL27749561 | 0.79 | MAPT (0.45) | KMT2ARAB9ALMNAALDH1A1HSD17B10 | |
| SCHEMBL28322888 | 0.79 | KMT2A (0.47) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL11632317 | 0.79 | KMT2A (0.50) | KMT2ANR4A2PKMTSHRCYP1A2 | |
| SCHEMBL11631620 | 0.79 | KMT2A (0.59) | KMT2ANR4A2PKMTSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082843-A | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-04-04 | — | — | US | disclosed |