Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.75 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | PPARD | Q03181 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL10709002 | 1.00 | ALOX15 (0.75) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Azelaic Acid SCHEMBL10711294 | 0.91 | ALOX15 (0.69) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL10710884 | 0.88 | ALOX15 (0.86) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Bicarbonate SCHEMBL10710896 | 0.88 | ALOX15 (0.86) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Oxalic Acid SCHEMBL10707552 | 0.86 | ALOX15 (1.00) | ALOX15AKR1B1ALDH1A1TDP1KDM4E | |
| Acetic Acid SCHEMBL10710664 | 0.86 | ALOX15 (0.82) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Carbamic Acid SCHEMBL27407387 | 0.86 | ALOX15 (0.82) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Oxalic Acid SCHEMBL283116 | 0.86 | ALOX15 (1.00) | ALOX15AKR1B1ALDH1A1TDP1KDM4E | |
| Stearic Acid SCHEMBL28227073 | 0.85 | GPR84 (0.68) | ALOX15AKR1B1GPR84PPARGPPARD | |
| Heptadecanoic Acid SCHEMBL28122553 | 0.85 | GPR84 (0.68) | ALOX15AKR1B1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106938-B1 | REACTION OF T-ALKYLHYDRAZINIUM SALTS AND ORGANIC PEROXIDES TO FOAM UNSATURATED POLYESTER RESINS | PENNWALT CORPORATION (US) | 1988-08-17 | — | — | EP | disclosed |
| EP-0220751-A2 | Foamable and cross-linkable unsaturated polyester composition | PENNWALT CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |