Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711782 | 0.86 | PGR (0.46) | PGRTDP1CYP3A4MAPTMEN1 | |
| SCHEMBL10713389 | 0.86 | PGR (0.55) | PGRTDP1CYP3A4MAPTCAPN9 | |
| SCHEMBL11427311 | 0.85 | PGR (0.50) | PGRTDP1CYP3A4CAPN9CASP3 | |
| SCHEMBL19370850 | 0.85 | PGR (0.50) | PGRTDP1CYP3A4CAPN9CASP3 | |
| SCHEMBL10715133 | 0.82 | PGR (0.72) | PGRMAPTGSK3B | |
| SCHEMBL10711063 | 0.77 | MEN1 (0.42) | PGRTDP1CYP3A4MAPTMEN1 | |
| SCHEMBL10714733 | 0.77 | TDP1 (0.43) | PGRTDP1CYP3A4MAPTCAPN9 | |
| SCHEMBL10713691 | 0.75 | GSK3B (0.40) | PGRTDP1CYP3A4MAPTMEN1 | |
| SCHEMBL10712231 | 0.74 | PGR (0.62) | PGRMAPTKMT2AGSK3B | |
| SCHEMBL10714017 | 0.72 | GRIA1 (0.49) | PGRMAPTPOLBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |