Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712665 | 0.81 | AHR (0.56) | AHRTDP2CASP3CASP7CASP9 | |
| SCHEMBL31116938 | 0.80 | AHR (0.60) | AHRTDP2CASP3CASP7CASP9 | |
| SCHEMBL10714481 | 0.80 | TDP2 (0.53) | AHRTDP2CASP3CASP7CASP9 | |
| SCHEMBL10711750 | 0.78 | CREBBP (0.53) | AHRTDP2MAPTCASP3CASP7 | |
| SCHEMBL23143481 | 0.77 | AHR (0.51) | AHRTDP2CASP3CASP7CASP9 | |
| SCHEMBL6320304 | 0.77 | GSK3B (0.52) | HDAC4HDAC2HDAC8MAPTRAB9A | |
| SCHEMBL1317350 | 0.74 | AHR (0.56) | AHRTDP2MAPTCASP3CASP7 | |
| SCHEMBL10712672 | 0.73 | AHR (0.58) | AHRTDP2CASP3CASP7CASP9 | |
| SCHEMBL155069 | 0.71 | PDE3B (0.62) | AHRTDP2PDE3BPDE3AABCB1 | |
| SCHEMBL4019289 | 0.71 | EIF2AK2 (0.63) | AHRTDP2MAPTRAB9APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |