Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 11/20 | 0.53 |
| ▸ | AHR | P35869 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP9 | P55211 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712665 | 0.85 | AHR (0.56) | TDP2AHRCASP3CASP7CASP9 | |
| SCHEMBL31116938 | 0.84 | AHR (0.60) | TDP2AHRCASP3CASP7CASP9 | |
| SCHEMBL23143481 | 0.81 | AHR (0.51) | TDP2AHRCASP3CASP7CASP9 | |
| SCHEMBL10714420 | 0.80 | AHR (0.47) | TDP2AHRCASP3CASP7CASP9 | |
| SCHEMBL10714275 | 0.79 | AHR (0.53) | TDP2AHRCASP3CASP7CASP9 | |
| SCHEMBL10710455 | 0.77 | TDP2 (0.49) | TDP2AHR | |
| SCHEMBL10714905 | 0.77 | TDP2 (0.52) | TDP2AHRGRIA1CACNG8 | |
| SCHEMBL10711419 | 0.77 | TDP2 (0.52) | TDP2AHRGRIA1CACNG8 | |
| SCHEMBL10712672 | 0.76 | AHR (0.58) | TDP2AHRCASP3CASP7CASP9 | |
| SCHEMBL1654363 | 0.75 | AHR (0.61) | TDP2AHRCASP3CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |