SCHEMBL10716838

SCHEMBL10716838

O=C1c2cccc(F)c2C(=O)c2cccc(F)c21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
ADORA2A P29274 2/20 0.46
PGR P06401 1/20 0.45
MAPT P10636 5/20 0.44
ALDH1A1 P00352 3/20 0.44
MAPK1 P28482 3/20 0.44
TDP1 Q9NUW8 3/20 0.44
LMNA P02545 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
MAOB P27338 1/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TTR P02766 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL760904 0.93 ADORA2A (0.57) MAOACA1CA2CA7CA9
SCHEMBL8916299 0.92 MAPT (0.54) MAOACA1CA2CA7CA9
SCHEMBL5866470 0.90 CA1 (0.52) MAOACA1CA2CA7CA9
SCHEMBL13487412 0.90 CA1 (0.52) MAOACA1CA2CA7CA9
SCHEMBL2072999 0.88 MAPT (0.52) MAOACA1CA2CA7CA9
SCHEMBL31307459 0.87 CA1 (0.43) MAOACA1CA2CA7CA9
SCHEMBL7805629 0.84 CA1 (0.44) MAOACA1CA2CA7CA9
SCHEMBL8669578 0.83 MEN1 (0.55) MAOACA1CA2CA7CA9
SCHEMBL13487411 0.83 PTPRC (0.59) MAOACA1CA2CA7CA9
SCHEMBL13487410 0.83 PTPRC (0.57) MAOACA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-62151422-A None JP disclosed
JP-62151421-A None JP disclosed
JP-S62151422-A THERMOPLASTIC AROMATIC POLYETHER SULFONE COPOLYMER AND PRODUCTION THEREOF TORAY IND INC 1987-07-06 JP disclosed
JP-S62151421-A THERMOPLASTIC AROMATIC POLYETHER KETONE COPOLYMER AND PRODUCTION THEREOF TORAY IND INC 1987-07-06 JP disclosed