Sugi Predict

Sugi Predict / Compounds / SCHEMBL107175

SCHEMBL107175

SCHEMBL107175

Cc1c(C(=O)O)ccc(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES2 O00748 3/20 0.50
▸ CES1 P23141 3/20 0.50
▸ CYP1A2 P05177 1/20 0.42
▸ MAP2K1 Q02750 2/20 0.41
▸ MAP2K2 P36507 1/20 0.41
▸ ALB P02768 1/20 0.41
▸ MYC P01106 2/20 0.41
▸ ADRA2A P08913 1/20 0.41
▸ CLCN2 P51788 1/20 0.41
▸ HDAC4 P56524 1/20 0.39
▸ TSHR P16473 2/20 0.39
▸ BCHE P06276 1/20 0.39
▸ NOTUM Q6P988 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ ASPH Q12797 1/20 0.38
▸ KDM8 Q8N371 1/20 0.38
▸ HAAO P46952 1/20 0.38
▸ GABRP O00591 1/20 0.38
▸ GABRD O14764 1/20 0.38
▸ GABRA1 P14867 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29465861 1.00 CES2 (0.50) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL14472134 0.84 CYP1A2 (0.44) CES2CES1CYP1A2ALBMYC
SCHEMBL26771502 0.83 CES2 (0.52) CES2CES1MAP2K1MAP2K2MYC
SCHEMBL109592 0.83 CLCN2 (0.45) CES2CES1CYP1A2MAP2K1ALB
SCHEMBL31158853 0.83 CLCN2 (0.45) CES2CES1CYP1A2MAP2K1ALB
SCHEMBL1192063 0.83 CES2 (0.45) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL30367318 0.83 HPGD (0.44) CYP1A2MYCADRA2ACLCN2TSHR
SCHEMBL7822093 0.83 HPGD (0.44) CYP1A2MYCADRA2ACLCN2TSHR
SCHEMBL26771499 0.83 CES2 (0.50) CES2CES1HDAC4TSHRBCHE
SCHEMBL23243439 0.81 CES2 (0.48) CES2CES1MAP2K1MAP2K2HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122059801-A Synthesis method of Marbalol Sha Wei side chain intermediate 重庆圣华曦药业股份有限公司 2026-05-19 — — CN claimed
CN-112858534-A HPLC detection method for baroxavir ester intermediate and related substances thereof 山东新华制药股份有限公司 2021-05-28 — — CN claimed
CN-110790690-A Synthetic method of 3, 4-difluoro-2- ((phenylthio) methyl) benzoic acid 湖南师范大学 2020-02-14 — — CN claimed
EP-1514864-B1 Difluoralkyl aromatic compounds SALTIGO GMBH (DE) 2008-03-19 — — EP claimed
EP-1514864-A2 Difluoralkyl aromatic compounds Bayer Chemicals AG (DE) 2005-03-16 — — EP claimed
US-20050054733-A1 Difluoroalkylaromatics LANXESS DEUTSCHLAND GMBH (DE) 2005-03-10 — — US claimed
CN-122059801-A Synthesis method of Marbalol Sha Wei side chain intermediate 重庆圣华曦药业股份有限公司 2026-05-19 — — CN disclosed
CN-122059801-A Synthesis method of Marbalol Sha Wei side chain intermediate 重庆圣华曦药业股份有限公司 2026-05-19 — — CN disclosed
EP-4692092-A1 NOVEL COMPOUNDS WITH MTORC2-INHIBITORY ACTIVITY AND USES THEREOF Aliad Biopharma (KR) 2026-02-11 — — EP disclosed
US-12544448-B2 C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors Revolution Medicines, Inc. (US) 2026-02-10 — — US disclosed
US-20250263399-A1 CBL-B MODULATORS AND USES THEREOF SCHRÖDINGER, INC. 2025-08-21 — — US disclosed
US-12325697-B2 CBL-B modulators and uses thereof NIMBUS CLIO, INC. (US) 2025-06-10 — — US disclosed
US-20250108117-A1 C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-04-03 — — US disclosed
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 — — EP disclosed
EP-0625505-B1 2-Cyano-1,3-dione derivatives and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1998-10-28 — — EP disclosed
EP-0759911-A1 4-BENZOYLISOXAZOLE DERIVATIVES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LTD. (GB) 1997-03-05 — — EP disclosed
WO-1995031446-A1 4-BENZOYLISOXAZOLE DERIVATIVES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LTD. (GB) 1995-11-23 — — WO disclosed
US-5374606-A Pre- and postemergence RHONE-POULENC AGRICULTURE LIMITED (GB) 1994-12-20 — — US disclosed
EP-0625505-A2 2-Cyano-1,3-dione derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-11-23 — — EP disclosed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250108117-A1 C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors MTOR, RICTOR, RPTOR CES2 3830/4885CES1 3116/4885CYP1A2 4804/4885
US-20250263399-A1 CBL-B MODULATORS AND USES THEREOF CBLB, CBL, CBLC CES2 3737/4885CES1 2390/4885CYP1A2 4603/4885
US-20050054733-A1 Difluoroalkylaromatics NQO1, TYR, FLI1 CES2 141/4885CES1 961/4885CYP1A2 88/4885
US-12325697-B2 CBL-B modulators and uses thereof CBLB, CBL, CBLC CES2 3737/4885CES1 2390/4885CYP1A2 4603/4885
US-12544448-B2 C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors RICTOR, MTOR, MLST8 CES2 4188/4885CES1 3902/4885CYP1A2 2040/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.