SCHEMBL10721352

CC(C)CC(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1)P(=O)(O)C(Cc1ccccc1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	2/20	0.52

▸	MME	P08473	4/20	0.47

▸	ECE1	P42892	3/20	0.47

▸	CTSB	P07858	1/20	0.47

▸	CTSK	P43235	1/20	0.47

▸	CASP3	P42574	1/20	0.46

▸	MMP2	P08253	1/20	0.46

▸	MMP7	P09237	1/20	0.46

▸	MMP9	P14780	1/20	0.46

▸	MMP8	P22894	1/20	0.46

▸	MMP14	P50281	1/20	0.46

▸	ANPEP	P15144	1/20	0.44

▸	ERAP1	Q9NZ08	1/20	0.44

▸	ACE2	Q9BYF1	1/20	0.43

▸	ACE	P12821	1/20	0.43

▸	CAPN1	P07384	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10725013	0.93	REN (0.53)	RENMMEECE1CTSBCTSK
SCHEMBL10722606	0.93	REN (0.53)	RENMMEECE1CTSBCTSK
SCHEMBL10724261	0.90	ANPEP (0.42)	RENMMP2MMP9MMP8ANPEP
SCHEMBL10724555	0.89	REN (0.53)	RENMMEECE1CTSBCTSK
SCHEMBL10720793	0.89	REN (0.53)	RENMMEECE1CTSBCTSK
SCHEMBL10725310	0.89	REN (0.53)	RENMMEECE1CTSBCTSK
SCHEMBL10725220	0.88	REN (0.47)	RENMMEECE1CTSBCTSK
SCHEMBL10725225	0.87	REN (0.43)	RENMMEECE1CTSBCTSK
SCHEMBL10724617	0.86	REN (0.51)	RENMMEECE1CTSBCTSK
SCHEMBL10720911	0.86	REN (0.51)	RENMMEECE1CTSBCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4698329-A	HYPOTENSIVE AGENTS	SANKYO COMPANY, LIMITED (JP)	1987-10-06	—	—	US	disclosed