Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277198 | 0.85 | SYK (0.60) | SYKCDK4CCND1CDK2CCNA2 | |
| SCHEMBL29813554 | 0.84 | EGFR (0.62) | CDK4CCND1CDK2FGFR1CCNA2 | |
| SCHEMBL3976815 | 0.76 | MAPK8 (0.61) | SYKLRRK2DCLK1CDK4CCND1 | |
| SCHEMBL12639329 | 0.75 | CDK4 (0.61) | SYKCDK4CCND1CDK2FGFR1 | |
| SCHEMBL26806030 | 0.75 | SYK (0.50) | SYKLRRK2DCLK1CDK4CCND1 | |
| SCHEMBL1019228 | 0.74 | JAK3 (0.66) | SYKJAK2JAK3MAPK8PTK2 | |
| SCHEMBL3973205 | 0.74 | CDK4 (0.73) | CDK4CCND1CDK2FGFR1CCNA2 | |
| SCHEMBL29576338 | 0.74 | STAT6 (0.56) | SYKLRRK2DCLK1CDK4CCND1 | |
| SCHEMBL16581017 | 0.74 | WEE1 (0.53) | SYKCDK4CCND1CDK2FGFR1 | |
| SCHEMBL3967392 | 0.74 | CDK4 (0.60) | SYKLRRK2DCLK1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |