Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | TTK | P33981 | 5/20 | 0.56 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.56 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 5/20 | 0.54 |
| ▸ | CCND1 | P24385 | 4/20 | 0.54 |
| ▸ | CCND3 | P30281 | 3/20 | 0.54 |
| ▸ | CCND2 | P30279 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.53 |
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813554 | 0.86 | EGFR (0.62) | TTKCDK4CCND1CCND3CCND2 | |
| SCHEMBL1072153 | 0.85 | SYK (0.55) | SYKJAK2CDK4CCND1CDK2 | |
| SCHEMBL1674211 | 0.82 | JAK2 (0.59) | SYKJAK2TTKTTBK1TTBK2 | |
| SCHEMBL7991106 | 0.80 | TTBK1 (0.56) | SYKJAK2TTKTTBK1TTBK2 | |
| SCHEMBL413904 | 0.79 | TTBK1 (0.55) | SYKJAK2TTKTTBK1TTBK2 | |
| SCHEMBL4378562 | 0.79 | TTK (0.66) | JAK2TTKTTBK1TTBK2AURKA | |
| SCHEMBL24243309 | 0.78 | TTK (0.67) | JAK2TTKTTBK1TTBK2AURKA | |
| SCHEMBL8083844 | 0.78 | TTK (0.62) | JAK2TTKTTBK1TTBK2AURKA | |
| SCHEMBL29576176 | 0.77 | SYK (0.60) | SYKJAK2IGF1RCDK4CCND1 | |
| SCHEMBL1360345 | 0.76 | PIK3CA (0.58) | TTBK1TTBK2IGF1RMAPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263940-A | FGFR inhibitor, preparation method thereof, pharmaceutical composition and application | 中国药科大学 | 2023-12-22 | — | — | CN | disclosed |