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SCHEMBL10722734

SCHEMBL10722734

CCC(C)CNC(=O)CP(=O)(O)C(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 14/20 0.54
▸ CTSB P07858 1/20 0.46
▸ CTSK P43235 1/20 0.46
▸ ANPEP P15144 1/20 0.43
▸ ERAP1 Q9NZ08 1/20 0.43
▸ CASP3 P42574 1/20 0.43
▸ MMP2 P08253 1/20 0.43
▸ MMP7 P09237 1/20 0.43
▸ MMP9 P14780 1/20 0.43
▸ MMP8 P22894 1/20 0.43
▸ MMP14 P50281 1/20 0.43
▸ MME P08473 1/20 0.42
▸ ECE1 P42892 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10724617 0.93 REN (0.51) RENCTSBCTSKANPEPERAP1
SCHEMBL10720911 0.93 REN (0.51) RENCTSBCTSKANPEPERAP1
SCHEMBL10720793 0.90 REN (0.53) RENCTSBCTSKANPEPERAP1
SCHEMBL10725310 0.90 REN (0.53) RENCTSBCTSKANPEPERAP1
SCHEMBL10724555 0.90 REN (0.53) RENCTSBCTSKANPEPERAP1
SCHEMBL10725450 0.89 REN (0.50) RENCTSBCTSKANPEPERAP1
SCHEMBL10722700 0.86 REN (0.70) REN
SCHEMBL10722259 0.86 REN (0.70) REN
SCHEMBL10721133 0.86 REN (0.70) REN
SCHEMBL10721140 0.86 REN (0.70) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4698329-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1987-10-06 — — US disclosed
EP-0152255-A2 New renin-inhibitory peptides and their use SANKYO COMPANY LIMITED (JP) 1985-08-21 — — EP disclosed
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