SCHEMBL10725450

CCC(C)[C@@H](CO)NC(=O)CP(=O)(O)C(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	8/20	0.50

▸	CTSB	P07858	1/20	0.48

▸	CTSK	P43235	1/20	0.48

▸	ANPEP	P15144	1/20	0.42

▸	ERAP1	Q9NZ08	1/20	0.42

▸	MMP2	P08253	3/20	0.42

▸	MMP9	P14780	3/20	0.42

▸	MMP8	P22894	3/20	0.42

▸	MMP14	P50281	3/20	0.42

▸	CASP3	P42574	1/20	0.42

▸	MMP7	P09237	1/20	0.42

▸	MME	P08473	3/20	0.41

▸	ECE1	P42892	3/20	0.41

▸	ACE2	Q9BYF1	1/20	0.39

▸	CTSD	P07339	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10720236	0.91	CTSB (0.49)	RENCTSBCTSKANPEPERAP1
SCHEMBL10725349	0.91	CTSK (0.56)	RENCTSBCTSKCASP3MME
SCHEMBL10722068	0.90	CTSB (0.48)	RENCTSBCTSKANPEPERAP1
SCHEMBL10720911	0.89	REN (0.51)	RENCTSBCTSKANPEPERAP1
SCHEMBL10724617	0.89	REN (0.51)	RENCTSBCTSKANPEPERAP1
SCHEMBL10720793	0.89	REN (0.53)	RENCTSBCTSKANPEPERAP1
SCHEMBL10725310	0.89	REN (0.53)	RENCTSBCTSKANPEPERAP1
SCHEMBL10724555	0.89	REN (0.53)	RENCTSBCTSKANPEPERAP1
SCHEMBL10722734	0.89	REN (0.54)	RENCTSBCTSKANPEPERAP1
SCHEMBL10975886	0.88	REN (0.56)	RENCTSBCTSKCASP3MME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4698329-A	HYPOTENSIVE AGENTS	SANKYO COMPANY, LIMITED (JP)	1987-10-06	—	—	US	disclosed