SCHEMBL10723748

SCHEMBL10723748

Nc1cccc2c1C(=O)c1cccc(NC(=O)c3cc(Cl)ccc3Cl)c1C2=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.53
ALDH1A1 P00352 6/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 1/20 0.51
CASP3 P42574 1/20 0.51
RORC P51449 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
LMNA P02545 2/20 0.46
POLB P06746 1/20 0.46
FADS1 O60427 1/20 0.46
MAOA P21397 1/20 0.46
MEN1 O00255 1/20 0.44
MMP14 P50281 1/20 0.44
KMT2A Q03164 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
HPGD P15428 1/20 0.44
CYP2C19 P33261 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10723733 0.96 KDM4E (0.52) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL10726128 0.88 CASP3 (0.66) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL10728647 0.85 MEN1 (0.63) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL11146215 0.84 CASP3 (0.47) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL10750834 0.84 CASP3 (0.65) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL10723741 0.84 MEN1 (0.54) KDM4EALDH1A1CASP3SMN1; SMN2MEN1
SCHEMBL10726032 0.84 MEN1 (0.56) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL11143862 0.81 CASP3 (0.46) KDM4EALDH1A1NPC1RAB9ACASP3
SCHEMBL10723796 0.81 MEN1 (0.50) KDM4EALDH1A1CASP3MEN1MMP14
SCHEMBL10728256 0.80 MEN1 (0.52) KDM4EALDH1A1NPC1RAB9ACASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4709019-A COLORFAST PIGMENTS BAYER AKTIENGESELLSCHAFT (DE) 1987-11-24 US disclosed
EP-0043937-B1 ANTHRAQUINONE-AZO COMPOUNDS, THEIR PREPARATION AND THEIR USE BAYER AG (DE) 1984-09-19 EP disclosed
EP-0058866-B1 ANTHRAQUINONE-AZO COMPOUNDS, THEIR PREPARATION AND USE BAYER AG (DE) 1984-07-18 EP disclosed
EP-0023617-B1 ANTHRAQUINONE-AZO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PIGMENTS BAYER AG (DE) 1984-06-27 EP disclosed
US-4389215-A Anthraquinone-azomethine compounds, processes for their preparation and processes for dyeing synthetic fibre materials and for pigmenting organic macromolecular substances BAYER AKTIENGESELLSCHAFT (DE) 1983-06-21 US disclosed
EP-0023666-B1 ANTHRAQUINONE-AZOMETHINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AS WELL AS A PROCESS FOR PIGMENTING ORGANIC MACROMOLECULAR MATERIALS BAYER AG (DE) 1982-10-13 EP disclosed
EP-0058866-A1 Anthraquinone-azo compounds, their preparation and use BAYER AG (DE) 1982-09-01 EP disclosed
EP-0023648-B1 ANTHRAQUINONE-AZOMETHINE COMPOUNDS, PROCESS FOR THEIR PREPARATION; PROCESS FOR DYEING SYNTHETIC FIBRE MATERIALS AS WELL AS FOR PIGMENTING ORGANIC MACROMOLECULAR MATERIALS BAYER AG (DE) 1982-06-23 EP disclosed
US-4323670-A Anthraquinone-azomethine compounds, processes for their preparation and processes for pigmenting organic macromolecular substances BAYER AKTIENGESELLSCHAFT (DE) 1982-04-06 US disclosed
US-4319025-A Anthraquinone-azomethine compounds, processes for their preparation and processes for dyeing synthetic fibre materials and for pigmenting organic macromolecular substances BAYER AKTIENGESELLSCHAFT (DE) 1982-03-09 US disclosed
EP-0043937-A2 Anthraquinone-azo compounds, their preparation and their use BAYER AG (DE) 1982-01-20 EP disclosed
EP-0023617-A1 Anthraquinone-azo compounds, process for their preparation and their use as pigments BAYER AG (DE) 1981-02-11 EP disclosed
EP-0023666-A1 Anthraquinone-azomethine compounds, process for their preparation as well as a process for pigmenting organic macromolecular materials BAYER AG (DE) 1981-02-11 EP disclosed
EP-0023648-A1 Anthraquinone-azomethine compounds, process for their preparation; process for dyeing synthetic fibre materials as well as for pigmenting organic macromolecular materials BAYER AG (DE) 1981-02-11 EP disclosed