Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724459 | 1.00 | REN (0.54) | RENCTSBCTSKCTSDCASP3 | |
| SCHEMBL10720131 | 0.93 | REN (0.60) | RENCTSBCTSK | |
| SCHEMBL10720136 | 0.93 | REN (0.60) | RENCTSBCTSK | |
| SCHEMBL10724362 | 0.93 | REN (0.60) | RENCTSBCTSK | |
| SCHEMBL10720805 | 0.93 | REN (0.60) | RENCTSBCTSK | |
| SCHEMBL10720794 | 0.93 | REN (0.60) | RENCTSBCTSK | |
| SCHEMBL10975883 | 0.91 | REN (0.56) | RENCTSBCTSKCASP3MME | |
| SCHEMBL10975886 | 0.91 | REN (0.56) | RENCTSBCTSKCASP3MME | |
| SCHEMBL10722764 | 0.90 | REN (0.58) | RENCTSBCTSKCTSDCASP3 | |
| SCHEMBL10722602 | 0.90 | REN (0.58) | RENCTSBCTSKCTSDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698329-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0152255-A2 | New renin-inhibitory peptides and their use | SANKYO COMPANY LIMITED (JP) | 1985-08-21 | — | — | EP | disclosed |