Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10806820 | 0.94 | PDE3B (0.46) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10726907 | 0.93 | PDE3B (0.45) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10729489 | 0.92 | PDE3B (0.44) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10726544 | 0.92 | PDE3B (0.44) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10724335 | 0.92 | PDE3B (0.44) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10724391 | 0.92 | PDE3B (0.44) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10650666 | 0.89 | PDE3B (0.49) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10727098 | 0.79 | PDE3B (0.39) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10724269 | 0.78 | PDE3B (0.42) | PDE3BPDE3ATSHRPDE2APDE1A | |
| SCHEMBL10646442 | 0.78 | PDE3B (0.46) | PDE3BPDE3ATSHRLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |