Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10726907 | 0.97 | PDE3B (0.45) | PDE3BPDE3AALDH1A1POLBKMT2A | |
| SCHEMBL10729489 | 0.96 | PDE3B (0.44) | PDE3BPDE3AALDH1A1POLBKMT2A | |
| SCHEMBL10726544 | 0.96 | PDE3B (0.44) | PDE3BPDE3AALDH1A1POLBKMT2A | |
| SCHEMBL10724391 | 0.96 | PDE3B (0.44) | PDE3BPDE3AALDH1A1POLBKMT2A | |
| SCHEMBL10724335 | 0.96 | PDE3B (0.44) | PDE3BPDE3AALDH1A1POLBKMT2A | |
| SCHEMBL10724467 | 0.94 | PDE3B (0.47) | PDE3BPDE3AALDH1A1POLBKMT2A | |
| SCHEMBL10650666 | 0.87 | PDE3B (0.49) | PDE3BPDE3AKMT2ALMNANPY1R | |
| SCHEMBL10648178 | 0.79 | PDE3B (0.44) | PDE3BPDE3ALMNAMAPK1CYP1A2 | |
| SCHEMBL11119254 | 0.78 | HRH3 (0.54) | PDE3BPDE3ALMNANPY1RNPY2R | |
| SCHEMBL10727098 | 0.77 | PDE3B (0.39) | PDE3BPDE3AKMT2ALMNANPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |