SCHEMBL10724655

CCCC[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)CC)[C@@H](O)CC(=O)N[C@H](CO)[C@@H](C)CC

nearest known ligand 0.51

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	13/20	0.51

▸	CTSB	P07858	1/20	0.47

▸	CTSK	P43235	1/20	0.47

▸	CASP3	P42574	1/20	0.46

▸	MME	P08473	1/20	0.44

▸	ACE	P12821	1/20	0.44

▸	CPA1	P15085	1/20	0.44

▸	ACE2	Q9BYF1	1/20	0.44

▸	CTSL	P07711	1/20	0.44

▸	CTSS	P25774	1/20	0.44

▸	CASP1	P29466	1/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10724650	1.00	REN (0.51)	RENCTSBCTSKCASP3MME
SCHEMBL10722719	0.92	REN (0.59)	RENCTSBCTSK
SCHEMBL10722714	0.92	REN (0.59)	RENCTSBCTSK
SCHEMBL10724666	0.92	CTSK (0.56)	RENCTSBCTSKCASP3
SCHEMBL10724673	0.92	CTSK (0.56)	RENCTSBCTSKCASP3
SCHEMBL10724618	0.90	REN (0.59)	RENCTSBCTSK
SCHEMBL10724611	0.90	REN (0.59)	RENCTSBCTSK
SCHEMBL10724146	0.90	REN (0.52)	RENCTSBCTSKCASP3MME
SCHEMBL10724153	0.90	REN (0.52)	RENCTSBCTSKCASP3MME
SCHEMBL10723630	0.89	REN (0.58)	RENCTSBCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4698329-A	HYPOTENSIVE AGENTS	SANKYO COMPANY, LIMITED (JP)	1987-10-06	—	—	US	disclosed