Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246359 | 0.86 | KDM5A (0.65) | KDM5APDE3BPDE3APARP1CHUK | |
| SCHEMBL29498328 | 0.80 | TNKS2 (0.56) | KDM5APDE3BPDE3APARP1FEN1 | |
| SCHEMBL29390241 | 0.79 | KDM5A (0.75) | KDM5APDE3BPDE3APARP1FEN1 | |
| SCHEMBL4754006 | 0.79 | KDM5A (0.75) | KDM5APDE3BPDE3APARP1FEN1 | |
| SCHEMBL4753109 | 0.79 | KDM5A (0.51) | KDM5APDE3BPDE3APARP1FEN1 | |
| SCHEMBL10730225 | 0.75 | KDM5A (0.47) | KDM5APDE3BPDE3APARP1FEN1 | |
| SCHEMBL31688848 | 0.73 | CYP1A2 (0.62) | PARP1AR | |
| SCHEMBL1770981 | 0.73 | CYP1A2 (0.62) | PARP1AR | |
| SCHEMBL12396546 | 0.72 | ACHE (0.61) | PDE3BPDE3APARP1FEN1ACHE | |
| SCHEMBL972999 | 0.71 | ACHE (0.78) | PARP1FEN1ACHECHUKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716170-A | 5-[1H-(5-membered-N-aromatic heteryl)-1-yl]-1,6-naphthyridin-2(1H)-ones and their cardiotonic use | STERLING DRUG INC. (US) | 1987-12-29 | — | — | US | disclosed |
| US-4697021-A | 1,6-dihydro-6-oxo-3-pyridinecarbonitriles, intermediates for cardiotonic agents | STERLING DRUG INC. (US) | 1987-09-29 | — | — | US | disclosed |
| US-4657915-A | INOTROPIC AGENTS | STERLING DRUG INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4634772-A | 2-[2-(di-lower-alkylamino)-1-propenyl]-6-methoxy-3-pyridinecarbonitriles, intermediates for cardiotonic agents | STERLING DRUG INC. (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0189853-A2 | 1,6-Naphthyridin-2(1H)-ones having cardiotonic activity and preparation | STERLING DRUG INC. (US) | 1986-08-06 | — | — | EP | disclosed |