Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 2/20 | 0.51 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29390241 | 1.00 | KDM5A (0.75) | KDM5AKDM4EALDH1A1DAOFEN1 | |
| Trifluoroacetic Acid SCHEMBL31704032 | 0.88 | KDM5A (0.60) | KDM5AKDM4EALDH1A1DAOFEN1 | |
| SCHEMBL3242090 | 0.86 | KDM5A (1.00) | KDM5AKDM4EALDH1A1DAOPARP1 | |
| SCHEMBL30064094 | 0.86 | KDM5A (1.00) | KDM5AKDM4EALDH1A1DAOPARP1 | |
| SCHEMBL29498328 | 0.80 | TNKS2 (0.56) | KDM5AKDM4EALDH1A1FEN1PARP1 | |
| SCHEMBL4753109 | 0.79 | KDM5A (0.51) | KDM5ADAOFEN1PARP1PDE3B | |
| SCHEMBL10724700 | 0.79 | KDM5A (0.51) | KDM5ADAOFEN1PARP1PDE3B | |
| SCHEMBL22434515 | 0.75 | FEN1 (0.54) | KDM5ADAOFEN1PARP1PDE3B | |
| SCHEMBL10730225 | 0.75 | KDM5A (0.47) | KDM5AFEN1PARP1PDE3BPDE3A | |
| SCHEMBL1193735 | 0.73 | KDM4E (1.00) | KDM5AKDM4EALDH1A1DAOAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111163775-B | Novel [1,6] naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors | 勃林格殷格翰国际有限公司 | 2023-07-11 | — | — | CN | disclosed |
| CN-111163775-A | Novel [1,6] naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors | 勃林格殷格翰国际有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-101466681-A | Tumor necrosis factor alpha inhibitors and their use in the treatment of human diseases | AVANIR PHARMACEUTICALS (US) | 2009-06-24 | — | — | CN | disclosed |
| EP-1996553-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | Avanir Pharmaceuticals (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20080139551-A1 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2008-06-12 | — | — | US | disclosed |
| WO-2007109251-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139551-A1 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | TNF, TNFRSF1A, TNFRSF9 | KDM5A 4732/4885KDM4E 4691/4885ALDH1A1 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.