Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.44 |
| ▸ | BACE1 | P56817 | 9/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10731177 | 0.93 | REN (0.55) | REN | |
| SCHEMBL10868633 | 0.93 | REN (0.55) | REN | |
| SCHEMBL10727422 | 0.86 | REN (0.48) | RENBACE1 | |
| SCHEMBL10825159 | 0.82 | REN (0.49) | RENBACE1 | |
| SCHEMBL10825155 | 0.82 | REN (0.49) | RENBACE1 | |
| SCHEMBL10825178 | 0.82 | REN (0.49) | RENBACE1 | |
| SCHEMBL10766573 | 0.81 | REN (0.56) | REN | |
| SCHEMBL10525394 | 0.80 | REN (0.57) | REN | |
| SCHEMBL10869206 | 0.80 | REN (0.59) | REN | |
| SCHEMBL10725717 | 0.80 | REN (0.59) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4616088-A | Amino acid ester and amide renin inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1986-10-07 | — | — | US | claimed |
| EP-0181071-A2 | Amino acid ester and amide renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1986-05-14 | — | — | EP | claimed |
| US-4665193-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-05-12 | — | — | US | disclosed |
| US-4616088-A | Amino acid ester and amide renin inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1986-10-07 | — | — | US | disclosed |