Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725721 | 0.93 | REN (0.59) | RENAPPPSEN1PSEN2APH1B | |
| SCHEMBL10869206 | 0.93 | REN (0.59) | RENAPPPSEN1PSEN2APH1B | |
| SCHEMBL10725717 | 0.93 | REN (0.59) | RENAPPPSEN1PSEN2APH1B | |
| SCHEMBL10825178 | 0.88 | REN (0.49) | RENBACE1PSEN1PSEN2APH1B | |
| SCHEMBL10825159 | 0.88 | REN (0.49) | RENBACE1PSEN1PSEN2APH1B | |
| SCHEMBL10825155 | 0.88 | REN (0.49) | RENBACE1PSEN1PSEN2APH1B | |
| SCHEMBL10727419 | 0.86 | REN (0.44) | RENBACE1 | |
| SCHEMBL10825119 | 0.86 | REN (0.58) | REN | |
| SCHEMBL10825108 | 0.83 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10825253 | 0.83 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4616088-A | Amino acid ester and amide renin inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1986-10-07 | — | — | US | claimed |
| EP-0181071-A2 | Amino acid ester and amide renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1986-05-14 | — | — | EP | claimed |
| US-4665193-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-05-12 | — | — | US | disclosed |
| US-4616088-A | Amino acid ester and amide renin inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1986-10-07 | — | — | US | disclosed |