Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.58 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.56 |
| ▸ | HNF4A | P41235 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 7/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | F7 | P08709 | 2/20 | 0.46 |
| ▸ | F3 | P13726 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10728796 | 1.00 | PTPN1 (0.58) | PTPN1PTPN2PTPN6KAT8HNF4A | |
| SCHEMBL10897735 | 0.85 | ALDH1A1 (0.43) | APPF7F3KDM4EALOX15 | |
| SCHEMBL10897739 | 0.85 | ALDH1A1 (0.43) | APPF7F3KDM4EALOX15 | |
| SCHEMBL11028146 | 0.83 | RARB (0.51) | APPF7F3KDM4EALOX15 | |
| SCHEMBL11028148 | 0.83 | RARB (0.51) | APPF7F3KDM4EALOX15 | |
| SCHEMBL16143781 | 0.83 | PTPN1 (0.56) | PTPN1PTPN2PTPN6APP | |
| SCHEMBL4322043 | 0.83 | PTPN1 (0.56) | PTPN1PTPN2PTPN6APP | |
| SCHEMBL28549529 | 0.82 | APP (0.61) | APPLCKKDM4EMAPTALOX15 | |
| SCHEMBL9680538 | 0.82 | APP (0.61) | APPLCKKDM4EMAPTALOX15 | |
| SCHEMBL30355320 | 0.82 | APP (0.61) | APPLCKKDM4EMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4692552-A | Protease inhibitors | G. D. SEARLE & CO. (US) | 1987-09-08 | — | — | US | claimed |
| US-4499295-A | Protease inhibitors | G. D. SEARLE & CO. (US) | 1985-02-12 | — | — | US | claimed |
| EP-0124905-A1 | Protease inhibitors | G.D. Searle & Co. (US) | 1984-11-14 | — | — | EP | claimed |
| US-4692552-A | Protease inhibitors | G. D. SEARLE & CO. (US) | 1987-09-08 | — | — | US | disclosed |
| EP-0124905-B1 | PROTEASE INHIBITORS | G.D. Searle & Co. (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4584397-A | Protease inhibitors | G. D. SEARLE & CO. (US) | 1986-04-22 | — | — | US | disclosed |
| US-4499295-A | Protease inhibitors | G. D. SEARLE & CO. (US) | 1985-02-12 | — | — | US | disclosed |