Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10735918 | 0.89 | LSS (0.38) | LSSESR1ESR2MAOBPPARD | |
| SCHEMBL10730137 | 0.88 | ESR1 (0.40) | LSSAPPESR1ESR2NPC1 | |
| SCHEMBL10731193 | 0.81 | LSS (0.39) | LSSDRD2 | |
| SCHEMBL10736474 | 0.81 | AKR1C3 (0.47) | MAPTSMN1; SMN2PPARD | |
| SCHEMBL10659748 | 0.80 | ALDH1A1 (0.43) | ESR1ESR2MAOBNPC1MAPT | |
| SCHEMBL10732793 | 0.79 | RAB9A (0.51) | NPC1MAPTRAB9ASMN1; SMN2DRD2 | |
| SCHEMBL10734618 | 0.76 | ESR1 (0.41) | LSSESR1ESR2MAOBNPC1 | |
| SCHEMBL5365388 | 0.76 | LSS (0.44) | LSSESR1ESR2DRD2 | |
| SCHEMBL10728517 | 0.76 | LSS (0.49) | LSSESR1ESR2MAOBMAPT | |
| SCHEMBL11290271 | 0.74 | PPARA (0.32) | NPC1SMN1; SMN2PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4644064-A | DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-02-17 | — | — | US | disclosed |
| US-4504669-A | DIURETIC | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-03-12 | — | — | US | disclosed |
| US-4452804-A | DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4427691-A | DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-01-24 | — | — | US | disclosed |