Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647873 | 0.86 | PBRM1 (0.48) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10729397 | 0.82 | PBRM1 (0.46) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL16157002 | 0.74 | PDE3B (0.61) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7296342 | 0.74 | PDE3B (0.61) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10646114 | 0.74 | PDE3A (0.63) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11268997 | 0.72 | PDE3B (0.62) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10620570 | 0.70 | PDE3B (0.63) | PDE3APDE3BPDE4BPDE4APDE4C | |
| Fumaric Acid SCHEMBL10725290 | 0.70 | PDE3B (0.54) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| Fumaric Acid SCHEMBL10725276 | 0.70 | PDE3B (0.54) | PBRM1PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10646441 | 0.70 | PBRM1 (0.49) | PBRM1PDE3APDE3BPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |