SCHEMBL1073145

SCHEMBL1073145

ONn1cnc2ncnc-2c1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27596757 0.70 LTA4H (0.35) LTA4H
SCHEMBL27606838 0.70 LTA4H (0.35) LTA4H
SCHEMBL27575444 0.69 LTA4H (0.44) LTA4H
SCHEMBL28235029 0.68 LTA4H (0.35) LTA4H
SCHEMBL26155647 0.65 LTA4H (0.33) LTA4H
SCHEMBL28182726 0.62 CDK5 (0.36) LTA4H
SCHEMBL5989213 0.52 HSP90AA1 (0.44)
SCHEMBL28486037 0.48
SCHEMBL5988863 0.44 ATM (0.35)
SCHEMBL373166 0.43 HSP90AA1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170183645-A1 COMPOSITION AND METHOD FOR DIVERSIFYING POLYPEPTIDE LIBRARIES ABZYME THERAPEUTICS LLC 2017-06-29 US claimed
US-20150119351-A1 THERAPY OF TUMORS AND INFECTIOUS AGENTS DEFICIENT IN METHYLTHIOADENOSINE PHOSPHORYLASE LUBIN ADAM (US) 2015-04-30 US claimed
US-8796241-B2 Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase LUBIN ADAM (US) 2014-08-05 US claimed
US-20120094947-A1 METHOD FOR THE SELECTIVE THERAPY OF DISEASE LUBIN ADAM (US) 2012-04-19 US claimed
EP-2192905-A2 METHOD FOR THE SELECTIVE THERAPY OF DISEASE Lubin, Adam (US) 2010-06-09 EP claimed
WO-2009032057-A2 METHOD FOR THE SELECTIVE THERAPY OF DISEASE LUBIN ADAM (US) 2009-03-12 WO claimed
US-12427151-B2 Compositions and method of treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-09-30 US disclosed
CN-117645968-B Application of prebiotics in promoting growth of staphylococcus epidermidis CCSM0322 上海应用技术大学 2024-11-12 CN disclosed
CN-117645968-A Application of prebiotics in promoting growth of staphylococcus epidermidis CCSM0322 上海应用技术大学 2024-03-05 CN disclosed
US-20220241288-A1 COMPOSITIONS AND METHOD OF TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-08-04 US disclosed
US-11260058-B2 Compositions and method of treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-01 US disclosed
WO-2021182895-A1 COSMETIC COMPOSITION FOR INCREASING BENEFICIAL BACTERIA OF SKIN 주식회사 엘지생활건강 2021-09-16 WO disclosed
US-10968444-B2 Methods for generating bispecific functional agents ABZYME THERAPEUTICS LLC (US) 2021-04-06 US disclosed
US-20060024739-A1 C. elegans gro-1 gene HEKIMI SIEGFRIED 2006-02-02 US disclosed
US-6949378-B1 a polynucleotide encodes a heterologous polypeptide which is green fluorescent protein (GFP) MCGILL UNIVERSITY (CA) 2005-09-27 US disclosed
JP-2004298190-A NEW THERMOSTABLE PROTEIN HAVING 6-N-HYDROXYAMINOPURINE METABOLIZING ACTIVITY OSAKA UNIV 2004-10-28 JP disclosed
WO-2002100530-A2 METHOD FOR CONTROLLING FERMENTATION DEGUSSA AG (DE) 2002-12-19 WO disclosed
EP-1059354-A2 Sequence-determined DNA fragments and corresponding polypeptides encoded thereby Ceres Incorporated (US) 2000-12-13 EP disclosed
EP-1009813-A1 THE PHYSIOLOGICAL CLOCK-RELATED GENES GRO-1, GOP-1, GOP-2, GOP-3, AND HAP-1 McGILL UNIVERSITY (CA) 2000-06-21 EP disclosed
WO-1999010482-A1 THE C. ELEGANS GRO-1 GENE MCGILL UNIVERSITY (CA) 1999-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12427151-B2 Compositions and method of treating cancer ERCC5, ERCC1, XPA LTA4H 2247/4885
US-11260058-B2 Compositions and method of treating cancer TP53, HCCS, TOP2A LTA4H 2483/4885
US-20220241288-A1 COMPOSITIONS AND METHOD OF TREATING CANCER TP53, POLI, BRCA1 LTA4H 2421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.