Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.51 |
| ▸ | FEN1 | P39748 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | TLR4 | O00206 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13689271 | 0.87 | AKR1C3 (0.66) | AKR1C3HDAC8PTGS1ALDH1A1LMNA | |
| SCHEMBL11433567 | 0.85 | PARP10 (0.55) | PTGS1ALDH1A1SMN1; SMN2ERCC5FEN1 | |
| SCHEMBL10839698 | 0.84 | AKR1C3 (0.62) | AKR1C3HDAC8PTGS1ALDH1A1LMNA | |
| SCHEMBL1358606 | 0.83 | CES2 (0.62) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL1416819 | 0.83 | KMT2A (0.55) | ALDH1A1LMNASMN1; SMN2NPC1MEN1 | |
| SCHEMBL10825923 | 0.81 | AKR1C3 (0.68) | AKR1C3HDAC8PTGS1ALDH1A1LMNA | |
| SCHEMBL11033672 | 0.81 | MAOB (0.68) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL563746 | 0.79 | PARP10 (0.58) | AKR1C3HDAC8ERCC5FEN1NPC1 | |
| SCHEMBL8767835 | 0.79 | AKR1C3 (0.64) | AKR1C3HDAC8PTGS1ALDH1A1LMNA | |
| SCHEMBL187606 | 0.78 | TDP1 (0.52) | ALDH1A1LMNASMN1; SMN2NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4328356-A | Process for preparing esters of arylacetic acids from alpha-halo-alkylarylketones | MONTEDISON S.P.A. (IT) | 1982-05-04 | — | — | US | claimed |
| US-4654438-A | Manufacture of alpha-arylalkanoic acids and precursors | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1987-03-31 | — | — | US | disclosed |
| US-4542237-A | Manufacture of alpha-arylalkanoic acids and precursors | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-09-17 | — | — | US | disclosed |
| EP-0064394-A1 | Manufacture of alpha-arylalkanoic acids and precursors | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-11-10 | — | — | EP | disclosed |
| US-4328356-A | Process for preparing esters of arylacetic acids from alpha-halo-alkylarylketones | MONTEDISON S.P.A. (IT) | 1982-05-04 | — | — | US | disclosed |