Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 14/20 | 0.64 |
| ▸ | ACE2 | Q9BYF1 | 7/20 | 0.64 |
| ▸ | PREP | P48147 | 1/20 | 0.55 |
| ▸ | FAP | Q12884 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10733989 | 1.00 | ACE (0.64) | ACEACE2PREPFAPTSHR | |
| SCHEMBL9098688 | 0.89 | ACE (0.74) | ACEACE2 | |
| SCHEMBL7272049 | 0.89 | ACE (0.74) | ACEACE2 | |
| SCHEMBL10736853 | 0.87 | ACE (0.61) | ACEACE2 | |
| SCHEMBL11435575 | 0.87 | ACE (0.71) | ACEACE2PREPFAPTSHR | |
| SCHEMBL3472327 | 0.87 | ACE (0.71) | ACEACE2PREPFAPTSHR | |
| SCHEMBL29749309 | 0.87 | ACE (0.71) | ACEACE2PREPFAPTSHR | |
| SCHEMBL10942786 | 0.86 | ACE (0.58) | ACEACE2PREPFAPTSHR | |
| SCHEMBL10940312 | 0.86 | ACE (0.58) | ACEACE2PREPFAPTSHR | |
| SCHEMBL10940307 | 0.86 | ACE (0.58) | ACEACE2PREPFAPTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4642315-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4587234-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1986-05-06 | — | — | US | disclosed |
| US-4499079-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |