Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | VNN1 | O95497 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978849 | 0.83 | LMNA (0.48) | VNN1LMNAMAPTRXRARXRB | |
| SCHEMBL8648768 | 0.78 | CA1 (0.52) | LMNAMAPTPOLBALDH1A1HPGD | |
| SCHEMBL13488375 | 0.73 | SLC6A2 (0.63) | HCAR2FFAR1FFAR4CA1CA2 | |
| SCHEMBL10214927 | 0.72 | ALDH1A1 (0.54) | LMNAF2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL28178057 | 0.72 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1 | |
| SCHEMBL8784920 | 0.71 | ALDH1A1 (0.52) | LMNAMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL992039 | 0.71 | HCAR2 (0.58) | HCAR2F2ALDH1A1 | |
| SCHEMBL5816921 | 0.70 | FFAR1 (0.62) | VNN1FFAR1FFAR4ALDH1A1CA1 | |
| SCHEMBL11881329 | 0.70 | CA1 (0.68) | VNN1FFAR1FFAR4ALDH1A1HPGD | |
| Benzophenone SCHEMBL29263944 | 0.69 | HDAC8 (0.61) | VNN1ALDH1A1L3MBTL1CA2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4652559-A | ANALGESIC, ANTIDEPRESSANT | THE UPJOHN COMPANY (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0085811-B1 | 2-(PHENYLMETHYLENE)CYCLOALKYLAMINES | THE UPJOHN COMPANY (US) | 1986-05-07 | — | — | EP | disclosed |
| US-4540690-A | ANALGESICS, ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0085811-A1 | 2-(Phenylmethylene)cycloalkylamines | THE UPJOHN COMPANY (US) | 1983-08-17 | — | — | EP | disclosed |