Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10732354 | 0.83 | HCAR3 (0.55) | PRSS1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7973995 | 0.76 | PRSS1 (0.50) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL7970325 | 0.75 | PTGER4 (0.50) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL7970533 | 0.72 | PTGER4 (0.72) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL7960468 | 0.71 | PTGER4 (0.50) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL7960466 | 0.70 | PTGER4 (0.52) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL29513036 | 0.69 | PRSS1 (0.71) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL22428322 | 0.69 | PRSS1 (0.71) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL15585986 | 0.68 | SMN1; SMN2 (0.46) | PRSS1SMN1; SMN2BRCA1HIF1A | |
| SCHEMBL5881658 | 0.68 | HPGD (0.49) | PRSS1KDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4699909-A | CARDIOTONICS, HYPOTENSIVES AND ANTITHROMBOTICS | DR. KARL THOMAE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| US-4616018-A | CARDIOTOINC AGENTS, HYPOTENSIVES, AND ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1986-10-07 | — | — | US | disclosed |