Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10619509 | 0.99 | TSHR (0.55) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL5280630 | 0.77 | TSHR (0.61) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL5280636 | 0.77 | TSHR (0.61) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL11706811 | 0.76 | TSHR (0.64) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL11706807 | 0.76 | TSHR (0.64) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL155224 | 0.74 | CYP3A4 (0.57) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL22402644 | 0.74 | CYP3A4 (0.57) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL139932 | 0.74 | CYP3A4 (0.57) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL11847105 | 0.73 | CYP3A4 (0.59) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL11843450 | 0.73 | CYP3A4 (0.59) | TSHRCYP3A4CYP2D6THPOPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0870757-B1 | Fluoro-substituted adamantane derivatives | PFIZER (US) | 2002-06-12 | — | — | EP | claimed |
| US-6057364-A | USED FOR TREATING NEUROLOGICAL DISORDERS, SUCH AS MEMORY LOSS AND PARKINSON'S DISEASE, AND BACTERIAL AND VIRAL INFECTIONS | PFIZER INC (US) | 2000-05-02 | — | — | US | claimed |
| EP-0870757-A2 | Fluoro-substituted adamantane derivatives | PFIZER INC. (US) | 1998-10-14 | — | — | EP | claimed |
| WO-1988008295-A1 | HAIR GROWTH INHIBITION USING SUBSTITUED AMIDINES OR GUANIDINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |
| US-4007181-A | ANTIARRHYTHMIA, DIURETIC | THE UPJOHN COMPANY (US) | 1977-02-08 | — | — | US | claimed |
| US-20110201665-A1 | Compositions, Methods, and Kits for Treating Influenza Viral Infections | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2011-08-18 | — | — | US | disclosed |
| US-20110028510-A1 | Compositions, Methods, and Kits for Treating Influenza Viral Infections | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2011-02-03 | — | — | US | disclosed |
| WO-2011001258-A1 | COMPOSITIONS, METHODS, AND KITS FOR TREATING VIRAL AND BACTERIAL INFECTIONS BY TOCOTRIENOLS, TOCOMONOENOLS, TOCODIENOLS, TOCOPHEROLS, AND THEIR DERIVATES | EVITA LIFE SCIENCE PTE. LTD (SG) | 2011-01-06 | — | — | WO | disclosed |
| WO-2010095041-A2 | COMPOSITIONS, METHODS, AND KITS FOR TREATING INFLUENZA VIRAL INFECTIONS | EXCRX (SINGAPORE) PTE.LTD. (SG) | 2010-08-26 | — | — | WO | disclosed |
| US-20060270742-A1 | Compositions and methods for the treatment of neurodegenerative diseases | COMBINATORX, INC. | 2006-11-30 | — | — | US | disclosed |
| WO-2006119295-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | COMBINATORX, INCORPORATED (US) | 2006-11-09 | — | — | WO | disclosed |
| EP-0870757-B1 | Fluoro-substituted adamantane derivatives | PFIZER (US) | 2002-06-12 | — | — | EP | disclosed |
| US-6057364-A | USED FOR TREATING NEUROLOGICAL DISORDERS, SUCH AS MEMORY LOSS AND PARKINSON'S DISEASE, AND BACTERIAL AND VIRAL INFECTIONS | PFIZER INC (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0870757-A2 | Fluoro-substituted adamantane derivatives | PFIZER INC. (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1988008295-A1 | HAIR GROWTH INHIBITION USING SUBSTITUED AMIDINES OR GUANIDINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |
| US-4007181-A | ANTIARRHYTHMIA, DIURETIC | THE UPJOHN COMPANY (US) | 1977-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270742-A1 | Compositions and methods for the treatment of neurodegenerative diseases | PSEN2, PSEN1, HTT | TSHR 4729/4885CYP3A4 4742/4885CYP2D6 4670/4885 |
| US-20110201665-A1 | Compositions, Methods, and Kits for Treating Influenza Viral Infections | IL5, CCL5, CCL11 | TSHR 4258/4885CYP3A4 2335/4885CYP2D6 3350/4885 |
| US-20110028510-A1 | Compositions, Methods, and Kits for Treating Influenza Viral Infections | IL5, CCL5, CCL11 | TSHR 4258/4885CYP3A4 2335/4885CYP2D6 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.