Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 2/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10736619 | 1.00 | PRKCA (0.49) | PRKCAPRKCDPRKCGPRKCBPRKCH | |
| SCHEMBL10736607 | 1.00 | PRKCA (0.49) | PRKCAPRKCDPRKCGPRKCBPRKCH | |
| SCHEMBL7757693 | 0.91 | — | — | |
| SCHEMBL7401650 | 0.79 | GRM2 (0.42) | PRKCAPRKCD | |
| SCHEMBL7401646 | 0.79 | GRM2 (0.42) | PRKCAPRKCD | |
| SCHEMBL11356361 | 0.79 | SSTR2 (0.44) | — | |
| SCHEMBL7401654 | 0.79 | GRM2 (0.42) | PRKCAPRKCD | |
| SCHEMBL7405668 | 0.79 | GRM2 (0.42) | PRKCAPRKCD | |
| SCHEMBL7405665 | 0.79 | GRM2 (0.42) | PRKCAPRKCD | |
| SCHEMBL7397347 | 0.78 | PRKCA (0.40) | PRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4710513-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1987-12-01 | — | — | US | disclosed |
| US-4567289-A | ANTICHOLESTEROL ANTILIPEMIC | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4459422-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1984-07-10 | — | — | US | disclosed |
| US-4375475-A | ANTICHOLESTEROL AGENTS | MERCK & CO., INC. (US) | 1983-03-01 | — | — | US | disclosed |
| EP-0024348-A1 | Substituted 6-Phenethyl-and phenylethenyl-3,4,5,6-tetrahydro-4-hydroxytetraydropyran-2-ones in the4-R trans stereoisomeric forms and the corresponding dihydroxy acids, process for preparing and pharmaceutical composition comprising them | MERCK & CO. INC. (US) | 1981-03-04 | — | — | EP | disclosed |