⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10736607 | 0.91 | PRKCA (0.49) | — | |
| SCHEMBL10736601 | 0.91 | PRKCA (0.49) | — | |
| SCHEMBL10736619 | 0.91 | PRKCA (0.49) | — | |
| SCHEMBL8352429 | 0.83 | CYP3A4 (0.60) | — | |
| SCHEMBL10385911 | 0.80 | HMGCR (0.49) | — | |
| SCHEMBL9267781 | 0.78 | LMNA (0.55) | — | |
| SCHEMBL6282511 | 0.78 | LMNA (0.55) | — | |
| SCHEMBL11354198 | 0.77 | SLC6A2 (0.50) | — | |
| SCHEMBL7080429 | 0.76 | CYP3A4 (0.54) | — | |
| SCHEMBL5671815 | 0.76 | CYP3A4 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6278001-B1 | REACTING TRI-ANION OF ALKYL 3,5-DIOXOHEXANOATE COMPOUND WITH MENTHYL-P-TOLUENESULPHINATE COMPOUND; REDUCTION TO FORM HYDROXYL GROUPS; PROTECTING HYDROXYL GROUPS; REDUCTION OF SULPHOXIDE GROUP; FORMING ALDEHYDE GROUP; WITTIG REACTION | L'ORÉAL (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-0805800-B1 | METHOD FOR PREPARING (+)COMPACTIN AND (+)MEVINOLIN ANALOG COMPOUNDS HAVING A BETA-HYDROXY-DELTA-LACTONE GROUPING | OREAL (FR) | 2001-03-14 | — | — | EP | disclosed |
| EP-0805800-A1 | METHOD FOR PREPARING (+)COMPACTIN AND (+)MEVINOLIN ANALOG COMPOUNDS HAVING A BETA-HYDROXY-DELTA-LACTONE GROUPING | L'OREAL (FR) | 1997-11-12 | — | — | EP | disclosed |
| WO-1997019917-A1 | METHOD FOR PREPARING (+)COMPACTIN AND (+)MEVINOLIN ANALOG COMPOUNDS HAVING A β-HYDROXY-δ-LACTONE GROUPING | L'OREAL (FR) | 1997-06-05 | — | — | WO | disclosed |