Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10804527 | 0.79 | TGFBR1 (0.53) | TGFBR1CYP3A4CYP2C8SLC2A1AURKA | |
| SCHEMBL10840379 | 0.77 | TGFBR1 (0.53) | TGFBR1CYP3A4CYP2C8MAPKAPK2SLC2A1 | |
| SCHEMBL10738951 | 0.74 | TGFBR1 (0.44) | TGFBR1CYP3A4CYP2C8CCNB2CDK1 | |
| SCHEMBL21061188 | 0.67 | TRPM5 (0.42) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598342 | 0.66 | TGFBR1 (1.00) | TGFBR1CYP3A4CYP2C8MAP4K4 | |
| SCHEMBL21067190 | 0.66 | TGFBR1 (0.41) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598344 | 0.66 | TGFBR1 (1.00) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL22733555 | 0.65 | TGFBR1 (0.46) | TGFBR1CYP3A4CYP2C8SLC2A1 | |
| SCHEMBL2598458 | 0.65 | TGFBR1 (1.00) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL10507536 | 0.65 | TGFBR1 (0.40) | TGFBR1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207593-A1 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1987-01-07 | — | — | EP | claimed |
| US-4716160-A | Certain 7-amino-pyrazolo[4,3-b]pyridines useful in treating inflammatory and allergic disorders | BEECHAM GROUP P.L.C. (GB) | 1987-12-29 | — | — | US | disclosed |
| EP-0207593-A1 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1987-01-07 | — | — | EP | disclosed |