Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.56 |
| ▸ | RECQL | P46063 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | BLM | P54132 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | APEX1 | P27695 | 3/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553015 | 0.85 | TDP1 (0.60) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL30918749 | 0.84 | TDP1 (0.55) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL29196541 | 0.84 | TDP1 (0.55) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL11646585 | 0.83 | TDP1 (0.58) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL30918751 | 0.83 | TDP1 (0.58) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL29196542 | 0.83 | TDP1 (0.58) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL29196545 | 0.81 | TDP1 (0.51) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL30918748 | 0.81 | TDP1 (0.51) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL8442891 | 0.80 | ADRB2 (0.44) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL30918750 | 0.78 | TDP1 (0.49) | TDP1KDM4ERECQLMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4704407-A | Soluble dobutamine salts | ELI LILLY AND COMPANY (US) | 1987-11-03 | — | — | US | disclosed |