SCHEMBL107423

SCHEMBL107423

O=C(CCc1ccccc1)CCc1ccccc1.[Pd]

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.70
FFAR1 O14842 2/20 0.64
ALDH1A1 P00352 2/20 0.64
TDP1 Q9NUW8 3/20 0.60
TRPA1 O75762 2/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
HDAC2 Q92769 2/20 0.59
HDAC8 Q9BY41 2/20 0.59
HDAC6 Q9UBN7 2/20 0.59
HDAC1 Q13547 2/20 0.58
HDAC3 O15379 1/20 0.58
MAPK1 P28482 1/20 0.58
ADRA1A P35348 1/20 0.58
HDAC4 P56524 1/20 0.58
SLC6A3 Q01959 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC10 Q969S8 1/20 0.58
HDAC11 Q96DB2 1/20 0.58
HDAC9 Q9UKV0 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL497371 0.97 KEAP1 (0.73) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL712597 0.95 KEAP1 (0.70) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL5355399 0.89 KEAP1 (0.75) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL19561359 0.89 HDAC1 (0.69) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL31596300 0.89 TDP1 (0.76) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL26624571 0.89 KEAP1 (0.61) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL5598977 0.88 KEAP1 (0.67) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL19625551 0.87 MAPT (0.68) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL9705008 0.87 KEAP1 (0.59) KEAP1FFAR1ALDH1A1TDP1TRPA1
SCHEMBL4198137 0.87 KEAP1 (0.59) KEAP1FFAR1ALDH1A1TDP1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025119663-A1 HERBICIDAL DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2025-06-12 WO disclosed
US-20200339577-A1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-10-29 US disclosed
US-10745397-B2 1-Substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as EP4 receptor antagonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-08-18 US disclosed
EP-3325490-B1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS TAKEDA PHARMACEUTICALS CO (JP) 2019-12-18 EP disclosed
US-20180215754-A1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-08-02 US disclosed
EP-3325490-A1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS Takeda Pharmaceutical Company Limited (JP) 2018-05-30 EP disclosed
WO-2017014323-A1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-01-26 WO disclosed
WO-2016088903-A1 HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-06-09 WO disclosed
WO-2016021742-A1 HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-02-11 WO disclosed
CN-104327117-A 1-(2-arylindenyl) dicyclohexylphosphine and preparation method and application thereof UNIV HUAZHONG NORMAL 2015-02-04 CN disclosed
EP-1478463-A1 PROCESS FOR THE CARBONYLATION OF AN ETHYLENICALLY UNSATURATED COMPOUND AND CATALYST THEREFORE SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 2004-11-24 EP disclosed
EP-1476417-A1 PROCESSES FOR THE PREPARATION OF A CAROBXYLIC ANHYDRIDE AND USE OF THE CARBOXYLIC ANHYDRIDE AS AN ACYLATION AGENT SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 2004-11-17 EP disclosed
US-20040152715-A1 Cycloalkylene amide compounds as NR2B receptor antagonists KAWAI MAKOTO (JP) 2004-08-05 US disclosed
WO-2004054579-A1 2-PYRIDYL AND 2-PYRIMIDYL CYCLOALKYLENE AMIDE COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS PFIZER JAPAN INC. (JP) 2004-07-01 WO disclosed
WO-2003070370-A1 PROCESS FOR THE CARBONYLATION OF AN ETHYLENICALLY UNSATURATED COMPOUND AND CATALYST THEREFORE SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2003-08-28 WO disclosed
WO-2003070679-A1 PROCESSES FOR THE PREPARATION OF A CAROBXYLIC ANHYDRIDE AND USE OF THE CARBOXYLIC ANHYDRIDE AS AN ACYLATION AGENT SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2003-08-28 WO disclosed
EP-1105366-A1 DIVINYLSTILBENESULFONIC ACID DERIVATIVES Ciba SC Holding AG (CH) 2001-06-13 EP disclosed
WO-2001010854-A1 BENZOTHIAZOLE COMPOUNDS AND THEIR USE AS OPTICAL BRIGHTENERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-02-15 WO disclosed
WO-2000009471-A1 DIVINYLSTILBENESULFONIC ACID DERIVATIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-02-24 WO disclosed
CN-1241188-A Heterocyclylmethyl-substed pyrazol derivs. BAYER AG (DE) 2000-01-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10745397-B2 1-Substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as EP4 receptor antagonists PTGER4, PTGER1, PTGER3 KEAP1 1571/4885FFAR1 275/4885ALDH1A1 718/4885
US-20200339577-A1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS PTGER4, PTGER1, PTGER3 KEAP1 1571/4885FFAR1 275/4885ALDH1A1 718/4885
US-20180215754-A1 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS PTGER4, PTGER1, PTGER3 KEAP1 1571/4885FFAR1 275/4885ALDH1A1 718/4885
US-20040152715-A1 Cycloalkylene amide compounds as NR2B receptor antagonists GRIN1, GRIN3A, GRIN2A KEAP1 2526/4885FFAR1 135/4885ALDH1A1 1795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.