Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5538980 | 0.78 | KDM4E (0.61) | KDM4EMDM2NPC1RAB9AHRH3 | |
| SCHEMBL19658668 | 0.77 | KDM4E (0.51) | KDM4EMDM2NPC1RAB9AALDH1A1 | |
| SCHEMBL4500807 | 0.73 | KDM4E (0.56) | KDM4EMDM2NPC1RAB9AHRH3 | |
| SCHEMBL7356339 | 0.72 | ALDH1A1 (0.66) | KDM4EMDM2ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL1919434 | 0.72 | MEN1 (0.73) | KDM4ENPC1RAB9AALDH1A1TSHR | |
| SCHEMBL10332949 | 0.72 | HRH3 (0.62) | HRH3HTR1ADRD2DRD4DRD3 | |
| SCHEMBL10527898 | 0.72 | HRH3 (0.52) | KDM4EHRH3ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL4406529 | 0.71 | ALDH1A1 (0.60) | KDM4EMDM2ALDH1A1TDP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1371732 | 0.71 | ALDH1A1 (0.64) | KDM4EMDM2ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL2633644 | 0.71 | MEN1 (0.54) | KDM4EMDM2ALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668687-A | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | claimed |