Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303853 | 0.82 | ALDH1A1 (0.57) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL10541229 | 0.80 | GSR (0.54) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL1303634 | 0.80 | GSR (0.54) | GSRMMP2MMP9MMP8 | |
| SCHEMBL5058142 | 0.79 | GSR (0.61) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL1185872 | 0.79 | GSR (0.61) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL15556865 | 0.77 | GSR (0.59) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL28990483 | 0.77 | GSR (0.59) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL125350 | 0.77 | GSR (0.59) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL22584909 | 0.77 | GSR (0.59) | GSRMMP2MMP9MMP8ENPP2 | |
| SCHEMBL16923800 | 0.77 | GSR (0.59) | GSRMMP2MMP9MMP8ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670445-A | VASODILATORS | ELI LILLY AND COMPANY (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0113236-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES-PYRAZINES, AND -TRIAZINES | ELI LILLY AND COMPANY (US) | 1987-04-22 | — | — | EP | disclosed |
| US-4636502-A | Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines | ELI LILLY AND COMPANY (US) | 1987-01-13 | — | — | US | disclosed |
| US-4578387-A | VASODILATION; DERIVATIVES OF 2-PHENYL-5,6,7,8-TETRAHYDROIMADAZO/1,2-A/PYRAZINE | ELI LILLY AND COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| EP-0154494-A2 | Phenylimidazole inotropic agents | ELI LILLY AND COMPANY (US) | 1985-09-11 | — | — | EP | disclosed |
| US-4537889-A | PHENYL SUBSTITUTED IMIDAZO COMPOUNDS | ELI LILLY AND COMPANY (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0113236-A1 | Substituted imidazopyrimidines-pyrazines, and -triazines | ELI LILLY AND COMPANY (US) | 1984-07-11 | — | — | EP | disclosed |