Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368176 | 0.98 | L3MBTL1 (0.42) | L3MBTL1ALDH1A1HTTS1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL9582171 | 0.96 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1HTTS1PR1S1PR3 | |
| SCHEMBL4374453 | 0.96 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1HTTS1PR1S1PR3 | |
| SCHEMBL335433 | 0.91 | — | — | |
| SCHEMBL299670 | 0.91 | — | — | |
| SCHEMBL132799 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL14311857 | 0.89 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1HTTPIM1KMT2A | |
| Hydrochloric Acid SCHEMBL14888081 | 0.89 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1HTTPIM1KMT2A | |
| Hydrochloric Acid SCHEMBL2673114 | 0.89 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1HTTPIM1KMT2A | |
| SCHEMBL14411270 | 0.83 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1HTTS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695574-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-09-22 | — | — | US | disclosed |