Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10745646 | 0.81 | WDR5 (0.73) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL10747411 | 0.81 | WDR5 (0.42) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL10750669 | 0.79 | WDR5 (0.53) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL10745635 | 0.74 | WDR5 (0.48) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL219606 | 0.72 | WDR5 (0.56) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL21484047 | 0.71 | WDR5 (0.52) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL4839937 | 0.71 | WDR5 (0.90) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL10750608 | 0.70 | ALDH1A1 (0.51) | WDR5ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2813551 | 0.70 | PDCD1 (0.57) | WDR5IDO1 | |
| SCHEMBL10747533 | 0.68 | HRH3 (0.40) | WDR5ALDH1A1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670445-A | VASODILATORS | ELI LILLY AND COMPANY (US) | 1987-06-02 | — | — | US | disclosed |
| US-4578387-A | VASODILATION; DERIVATIVES OF 2-PHENYL-5,6,7,8-TETRAHYDROIMADAZO/1,2-A/PYRAZINE | ELI LILLY AND COMPANY (US) | 1986-03-25 | — | — | US | disclosed |