Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916818 | 0.84 | METAP2 (0.54) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10746714 | 0.80 | NPC1 (0.41) | CYP2D6SLC6A2SLC6A4SLC6A3TRPA1 | |
| SCHEMBL10749814 | 0.78 | METAP2 (0.34) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10746418 | 0.75 | METAP2 (0.40) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10746610 | 0.75 | MAPK1 (0.43) | CDK5CDK2MAPK1ROCK1AURKA | |
| SCHEMBL5916663 | 0.74 | METAP2 (0.54) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10501187 | 0.72 | METAP2 (0.45) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10501589 | 0.71 | METAP2 (0.61) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10749752 | 0.71 | CYP11B1 (0.43) | CYP2D6IDO1METAP2KDM4EMEN1 | |
| SCHEMBL10502470 | 0.69 | METAP2 (0.46) | CYP2D6IDO1HSP90AA1METAP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |