Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916802 | 0.84 | METAP2 (0.54) | HSD17B10TDP1ALDH1A1GLAHPGD | |
| SCHEMBL10746479 | 0.75 | ROCK2 (0.44) | MAPK1NOS1TDP1ALDH1A1HPGD | |
| SCHEMBL10747607 | 0.74 | KDM4E (0.41) | MAPK1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL10502530 | 0.73 | MPI (0.41) | TDP1ALDH1A1MAPTMETAP2 | |
| SCHEMBL10748809 | 0.72 | CYP3A4 (0.46) | TDP1ALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL10502616 | 0.70 | METAP2 (0.46) | HSD17B10TDP1ALDH1A1GLAHPGD | |
| SCHEMBL10501811 | 0.70 | MPI (0.48) | HSD17B10TDP1ALDH1A1GLAL3MBTL1 | |
| SCHEMBL10502354 | 0.70 | METAP2 (0.41) | HSD17B10TDP1ALDH1A1GLAHPGD | |
| SCHEMBL10748399 | 0.69 | CYP3A4 (0.39) | ALDH1A1KDM4ECYP3A4MAPTKMT2A | |
| SCHEMBL10501589 | 0.69 | METAP2 (0.61) | HSD17B10TDP1ALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |