Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916769 | 0.86 | METAP2 (0.57) | METAP2 | |
| SCHEMBL10748809 | 0.80 | CYP3A4 (0.46) | CYP1A2METAP2KDM4EMAPTTDP1 | |
| SCHEMBL10500974 | 0.78 | METAP2 (0.54) | METAP2KMT2AKDM4EMAPT | |
| SCHEMBL10502310 | 0.76 | METAP2 (0.52) | METAP2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10501283 | 0.73 | METAP2 (0.68) | METAP2MEN1KMT2AMAPT | |
| SCHEMBL10501743 | 0.73 | METAP2 (0.54) | METAP2KMT2AKDM4EMAPT | |
| SCHEMBL10501336 | 0.71 | METAP2 (0.50) | METAP2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10501640 | 0.71 | METAP2 (0.37) | METAP2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10502111 | 0.70 | METAP2 (0.68) | METAP2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10748399 | 0.70 | CYP3A4 (0.39) | METAP2KMT2AKDM4EMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |